Research progress on the role of macrophage polarization in drug-induced liver injury
10.11855/j.issn.0577-7402.1838.2025.0417
- VernacularTitle:巨噬细胞极化在药物性肝损伤中的作用研究进展
- Author:
Guo-Jing XING
1
;
Li-Fei WANG
;
Long-Long LUO
;
Yuan DENG
;
Zhen WANG
;
Xiao-Feng ZHENG
;
Xiao-Hui YU
;
Jiu-Cong ZHANG
Author Information
1. 解放军联勤保障部队第940医院消化内科,甘肃 兰州 730050;宁夏医科大学总医院消化内科,宁夏
- Keywords:
drug-induced liver injury;
macrophages;
macrophage polarization
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(11):1478-1484
- CountryChina
- Language:Chinese
-
Abstract:
Drug-induced liver injury(DILI)is a common adverse drug reaction in clinical practice,which can lead to acute liver failure and even death in severe cases.In recent years,with the continuous introduction of new drugs and the expansion of their usage,the incidence and mortality rates of DILI have shown an upward trend,posing significant challenges to public health and clinical treatment.Macrophages,as a crucial component of the innate immune system,exhibit high plasticity and heterogeneity.They can polarize into pro-inflammatory M1 type or anti-inflammatory M2 type in response to microenvironmental signals.Research has demonstrated that macrophage polarization plays a central regulatory role in the occurrence and progression of DILI by influencing various processes such as inflammatory responses,cell apoptosis,and tissue repair.This review focuses on elucidating the regulatory mechanisms and roles of macrophage polarization in DILI,providing a theoretical framework for developing precise immunotherapeutic strategies.
