Research progress on activation and blocking of cholinergic anti-inflammatory pathway
10.11855/j.issn.0577-7402.0563.2025.0801
- VernacularTitle:胆碱能抗炎通路的激活与阻断方法研究进展
- Author:
Yu-Qi LIU
1
;
Yu-Ru WANG
;
Wen-Yue JIA
;
Yu-Meng ZHANG
;
Yang LIU
;
Hui-Qin HAO
Author Information
1. 山西中医药大学第三临床学院,山西 晋中 030619
- Keywords:
cholinergic anti-inflammatory pathway;
α7 nicotinic acetylcholine receptor;
vagus nerve;
inflammation
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(11):1469-1477
- CountryChina
- Language:Chinese
-
Abstract:
The cholinergic anti-inflammatory pathway(CAP)is a neuroimmunoregulatory pathway that has attracted much attention in recent years.This pathway releases acetylcholine(ACh)by activating the vagus nerve.The binding of ACh to α7 nicotinic acetylcholine receptor receptors on the surface of macrophages can inhibit the release of proinflammatory factors,so as to effectively regulate the inflammatory response in the body.CAP plays a key role in suppressing excessive inflammatory responses and maintaining immune balance,providing a potential therapeutic pathway for a variety of inflammatory immune diseases.Research progress on the physiological function of CAP and its activation and blocking methods are reviewed in this paper,in order to provide new methods and ideas for treatment of inflammation-related diseases and exploring therapeutic drugs targeting CAP pathway.
