Research progress of tRNA-derived small RNA in respiratory diseases
10.11855/j.issn.0577-7402.1995.2025.0428
- VernacularTitle:tRNA衍生的小RNA在呼吸系统疾病中的作用研究进展
- Author:
Yi-Tong QU
1
;
Yan XU
;
Zhi-Wei GUAN
;
Lu MENG
;
Yin-Li LI
;
Jian-Li QIU
Author Information
1. 河南中医药大学第一附属医院儿科医院,河南 郑州 450000;河南中医药大学儿科医学院,河南 郑州 450000
- Keywords:
respiratory diseases;
transfer RNA-derived small RNA(tsRNA);
regulatory mechanism;
clinical value
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(11):1461-1468
- CountryChina
- Language:Chinese
-
Abstract:
Transfer RNA-derived small RNAs(tsRNAs)are a novel class of non-coding small RNAs,which have various biological functions such as regulating gene expression,protein translation,epigenetic inheritance,cell proliferation and apoptosis,and communication.tsRNA is abnormally expressed in respiratory system cancers,lung injury,pulmonary hypertension,childhood obstructive sleep apnea-hypopnea syndrome and respiratory virus infections,affecting the occurrence and development of these diseases.However,the regulatory mechanism of tsRNAs in respiratory diseases has not been fully elucidated yet.Therefore,this review introduces the sources,classification and detection methods of tsRNA,summarizes the biological functions of tsRNA in respiratory diseases,related regulatory mechanisms,and its application prospects as biomarker in clinical diagnosis and prognosis evaluation,aiming to provide new ideas for the diagnosis and treatment of respiratory diseases,and to provide reference for in-depth research on tsRNA regulation of respiratory diseases.
