Research progress on the mechanism of mitochondrial quality control system dysfunction in atherosclerosis
10.11855/j.issn.0577-7402.1440.2025.0729
- VernacularTitle:线粒体质量控制系统失调在动脉粥样硬化中作用机制的研究进展
- Author:
Yang GAO
1
;
Yu GUO
;
Dan-Dan LIU
;
He-Wei QIN
;
Yi-Ting ZHAO
;
Chang CHAI
Author Information
1. 河南中医药大学康复医学院,河南 郑州 450046
- Keywords:
atherosclerosis;
mitochondrial dynamics;
autophagy;
mitochondrial quality control
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(11):1451-1460
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis(AS)is an inflammatory cardiovascular disease characterized by plaque accumulation in the arterial wall,leading to increased morbidity and mortality of related cardiovascular disorders.The main pathological mechanisms of AS include lipid deposition,oxidative stress,and chronic inflammation,with disease progression involving endothelial cell dysfunction,macrophage polarization,foam cell formation,and smooth muscle cell proliferation or apoptosis.Mitochondria are essential organelles that provide energy for cellular metabolism,and the mitochondrial quality control(MQC)system is the fundamental mechanism maintaining mitochondrial functional homeostasis.MQC dysfunction can induce vascular phenotype changes through pathways such as oxidative stress,apoptosis,and inflammation,thereby promoting the progression of AS.Therefore,targeting MQC to regulate mitochondrial function may become a new direction for the treatment of AS.This review summarizes the molecular mechanisms of MQC,including mitochondrial biogenesis,mitochondrial dynamics,and mitochondrial autophagy(mitophagy),and further elucidates the role of abnormal MQC in the pathological processes of AS,aiming to provide a scientific basis for identifying potential targets to delay the progression of AS and developing related drugs.
