Correlation analysis between stenosis characteristics and trans-stenotic pressure gradient using a 3D-printed hemodynamic simulation system for cerebral venous sinuses
10.11855/j.issn.0577-7402.0687.2025.0919
- VernacularTitle:脑静脉窦3D打印血流动力学模拟系统对狭窄特征与跨狭窄压力梯度的相关性分析
- Author:
Jia-Hao ZHANG
1
;
Lei GENG
;
Zhi-Tao XIAO
;
Xing CHEN
;
Zhe JI
;
Xiang-Yu CAO
Author Information
1. 天津工业大学人工智能学院,天津 300387
- Keywords:
cerebral venous sinus stenosis;
3D-printed model;
pressure gradient;
hemodynamics;
stents
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(11):1426-1432
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between different degrees of cerebral venous sinus stenosis and the trans-stenotic pressure gradient using a 3D-printed hemodynamic simulation system for cerebral venous sinuses.Methods Based on the double elastic cavity model,a complete morphological model of the superior sagittal sinus,transverse sinus,and sigmoid sinuses was constructed using 3D printing technology.An in vitro hemodynamic simulation system incorporating pulsatile blood flow was established to simulate the hemodynamic environment of cerebral venous sinus stenosis.Using this system,both unilateral dominant drainage and bilateral balanced drainage were simulated.The degree of stenosis and the pressure upstream and downstream of the stenosis were measured.The pressure difference and pressure ratio were calculated to analyze the correlation between stenosis degree and the trans-stenotic pressure gradient.Results In the unilateral dominant drainage model,as the stenosis severity increased,the upstream pressure increased,whereas the downstream pressure remained relatively stable,leading to an increased pressure gradient between the two ends.The regression equation for stenosis degree(X)and pressure gradient(pressure difference ΔP)was:YΔP=1.962X-1.417(R=0.867,R2=0.753,P<0.001).In the bilateral balanced drainage model of cerebral venous sinuses,when the stenosis degree on one side of the model increased,the pressure gradient between the two ends changed slightly and eventually reached a stable state.The regression equation between X and ΔP was:YΔP=0.62X+1.047(R=0.98,R2=0.96,P<0.001).Conclusions Stenosis in cerebral venous sinuses with unilateral dominant drainage has a more significant impact on the pressure gradient,while unilateral stenosis in bilateral cerebral venous sinuses with balanced drainage has a smaller impact on the pressure gradient.This result suggests that for bilateral venous sinus stenosis,stent implantation can be prioritized in one side of the cerebral venous sinuses.
