Progress and challenges in the study of diagnosis and treatment of autoimmune premature ovarian insufficiency
10.11855/j.issn.0577-7402.1173.2025.0925
- VernacularTitle:自身免疫性早发性卵巢功能不全的诊治研究进展与挑战
- Author:
Xia-Fei FU
1
;
Yuan-Li HE
Author Information
1. 南方医科大学珠江医院妇产科,广东 广州 510280
- Keywords:
autoimmune premature ovarian insufficiency;
pathogenesis;
diagnosis;
treatment;
challenges
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(11):1347-1352
- CountryChina
- Language:Chinese
-
Abstract:
Autoimmune premature ovarian insufficiency(POI)is a gynecological endocrine disease mediated by autoimmune responses.It is characterized by a decline in ovarian function before the age of 40,which severely affects female fertility and overall health.In recent years,studies on the pathogenesis,diagnosis,and treatment of autoimmune POI have achieved significant progress with the deepening of research in immunology and reproductive medicine.In terms of pathogenesis,this disease involves a variety of autoantibodies,abnormal T-cell activation,and cytokine imbalance,but the specific molecular mechanism remains incompletely understood.In terms of diagnosis,it primarily relies on clinical symptoms,assessment of ovarian reserve function,and autoantibody screening.However,there is a lack of specific biomarkers to confirm immune factors(the key to diagnosing immune-mediated POI),making early diagnosis difficult.Regarding treatment,hormone replacement therapy(HRT)can alleviate hypoestrogenic symptoms,and assisted reproductive technology(ART)may address fertility issues in a subset of patients.Nevertheless,immunomodulatory therapies currently lack evidence-based regimens and proven efficacy,and long-term prognosis remains suboptimal.This review systematically summarizes the pathogenesis,diagnostic difficulties,and therapeutic challenges of autoimmune POI,aiming to provide references for clinical practice and future research,and to promote precise diagnosis,treatment,and management of this disease.
