Research progress on the roles and mechanisms of peripheral immune cells in Alzheimer's disease:focus on the gut microbiota

VernacularTitle:外周免疫细胞在阿尔茨海默病中的作用及机制研究进展:聚焦肠道菌群
Author: Ya-Ting CHEN ¹ ; Qing-Cheng CHEN ; Li HU ; Zhou LIU
Author Information

1. 广东医科大学附属医院神经内科,广东湛江 524001;广东医科大学附属医院神经病学研究所,广东湛江 524001;广东省衰老相关心脑疾病重点实验室,广东湛江 524001
Keywords: Alzheimer's disease; immune cells; gut microbiota; blood-brain barrier
From: Medical Journal of Chinese People's Liberation Army 2025;50(10):1338-1346
CountryChina
Language:Chinese
Abstract: Alzheimer's disease(AD)is a common neurodegenerative disease in the elderly.Increasing evidence shows that peripheral immune cells are involved in the occurrence and development of AD.Both gut microbiota dysbiosis and abnormalities of peripheral immune cells occur in the early stage of AD.The gut microbiota can influence the central nervous system through mechanisms such as the gut-brain axis and the regulatory effects on peripheral immune cells.AD treatment methods targeting the gut microbiota and immune cells have been receiving increasing attention.This review summarizes the regulatory effects and mechanisms of the gut microbiota on peripheral immune cells,as well as the research progress on the gut microbiota's roles in the occurrence and development of AD,aiming to provide new ideas for relevant research on the prevention,diagnosis,and treatment of AD.