Research progress on decidual natural killer cell education in recurrent pregnancy loss
10.11855/j.issn.0577-7402.0033.2025.0807
- VernacularTitle:蜕膜NK细胞教育在复发性流产中的研究进展
- Author:
Ya-Jing LI
1
;
Yu-Jing XIONG
;
Jie DONG
;
Xiao-Hong WANG
Author Information
1. 空军军医大学唐都医院妇产科生殖医学中心,陕西 西安 710038
- Keywords:
decidual natural killer cell;
recurrent pregnancy loss;
maternal-fetal interface;
major histocompatibility complex;
human leukocyte antigen;
killer cell immunoglobulin-like receptor;
CD94/NKG2
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(10):1332-1337
- CountryChina
- Language:Chinese
-
Abstract:
Decidual natural killer(dNK)cells are the most abundant immune cells in the decidua.The functional acquisition during dNK cell development depends on NK cell education,a process in which the highly polymorphic killer cell immunoglobulin-like receptors(KIRs)and CD94/NKG2s expressed on dNK cells bind to major histocompatibility complex(MHC)class Ⅰmolecules expressed by extravillous trophoblast(EVT)cells.This interaction regulates the effector functions of NK cells.dNK cells participate in the establishment and maintenance of pregnancy by modulating immune tolerance at the maternal-fetal interface.Defects in dNK cell education leading to dNK dysfunction are potential pathological mechanisms underlying adverse pregnancy outcomes such as recurrent pregnancy loss(RPL).This review summarizes the characteristics of dNK cells,dNK cell education and its key associated molecules,and the pathological mechanisms by which poorly educated dNK cells contribute to RPL,aiming to offer insights for predicting and improving pregnancy outcomes in RPL patients associated with dNK cell abnormalities.
