Research progress on the relationship between macrophage mitophagy and atherosclerosis

VernacularTitle:巨噬细胞线粒体自噬与动脉粥样硬化关系的研究进展
Author: Dan MA ¹ ; Ming ZHANG ; Yu-Lu YU ; Ting-Ting LIU ; Guo-Jun ZHAO
Author Information

1. 遵义医科大学药学院,贵州遵义 563000;广州医科大学附属清远医院/清远市人民医院心血管内科,广东清远 511518
Keywords: mitophagy; macrophages; atherosclerosis
From: Medical Journal of Chinese People's Liberation Army 2025;50(10):1325-1331
CountryChina
Language:Chinese
Abstract: Mitophagy is a specific type of autophagy that selectively eliminates damaged mitochondria to maintain mitochondrial activity and cellular homeostasis.In recent years,regulating mitophagy to preserve normal cellular functions has gradually become an important preventive and therapeutic strategy for many diseases.Macrophages are key participants in the formation of atherosclerosis(AS)plaques.Studies have shown that mitophagy may be involved in the development of AS by regulating macrophage homeostasis and physiological functions.This review summarizes the mechanisms by which mitophagy regulates macrophage lipid metabolism,inflammation,senescence,apoptosis and pyroptosis in AS,aiming to provide a new theoretical basis for mitophagy-mediated regulation in AS.