Research progress on macrophage polarization modulated by stem cells for spinal cord injury treatment
10.11855/j.issn.0577-7402.1624.2024.0712
- VernacularTitle:干细胞调控巨噬细胞极化缓解脊髓损伤的研究进展
- Author:
Dan-Dan LIU
1
;
He-Wei QIN
;
Yang GAO
;
Chang CHAI
;
Yi-Ting ZHAO
Author Information
1. 河南中医药大学康复医学院,河南 郑州 450046
- Keywords:
stem cells;
spinal cord injury;
macrophage polarization;
mesenchymal stem cells;
neural stem cells
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(9):1195-1208
- CountryChina
- Language:Chinese
-
Abstract:
Spinal cord injury(SCI)is a central nervous system disease that can lead to motor,sensory,and autonomic dysfunction.Depending on the state of immune microenvironment,macrophage polarization can differentiate into M1/M2 phenotypes.The regulation of macrophage polarization by stem cells in many pathophysiological processes of SCI has become a hot topic of research in recent years.This review summarizes the relationship between macrophage polarization and SCI,and how mesenchymal stem cells(MSCs)and neural stem cells(NSCs)regulate macrophage polarization to improve SCI through paracrine secretion,delivery molecules,derived exosomes,and metabolic reprogramming pathways.It also summarizes the mechanism by which stem cells regulate the macrophage polarization phenotypes to promote SCI recovery through signaling pathways such as Janus tyrosine kinase/signal transducer and activator of transcription(JAK/STAT),Notch,Toll-like receptor 4/nuclear factor kappa-B(TLR4/NF-κB),phosphatidylinositol 3 kinase/protein kinase B(PI3K/Akt).The aim is to provide theoretical support for the treatment of SCI by regulating macrophage polarization with stem cells and to offer new perspectives for exploring the mechanism of stem cell therapy for SCI.
