Research progress of autophagy and ferroptosis in diabetic kidney disease
10.11855/j.issn.0577-7402.2075.2025.0609
- VernacularTitle:自噬和铁死亡在糖尿病肾病中的研究进展
- Author:
Tai-Min ZHANG
1
;
Xi-Zhe ZHANG
;
Duo-Sen ZHANG
;
Ya-Dong MA
;
Tian LI
Author Information
1. 新疆医科大学第二临床医学院,新疆 乌鲁木齐 830001
- Keywords:
diabetic kidney disease;
autophagy;
ferroptosis
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(9):1186-1194
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease(DKD)is a microvascular complication of diabetes mellitus with a complex pathogenesis.Recent studies have revealed that autophagy and ferroptosis,as two forms of programmed cell death,exhibit dynamic interactions in DKD:autophagy maintains homeostasis by eliminating damaged organelles,while ferroptosis is driven by iron-dependent lipid peroxidation.Imbalance between the two exacerbates renal injury.This review systematically summarizes the signaling pathways and key regulatory factors related to autophagy and ferroptosis,as well as their interaction mechanisms[such as nuclear receptor coactivator 4(NCOA4)-mediated ferritinophagy,clock autophagy,and lipid autophagy].It further elaborates the molecular network by which these processes synergistically regulate DKD progression.Additionally,the potential of modern pharmaceuticals and active components of traditional Chinese medicine to improve kidney injury by targeting autophagy and ferroptosis is discussed,proposing that targeting their cross-talk pathways may provide novel therapeutic strategies for DKD,aiming to lay a theoretical foundation for the development of targeted intervention strategies and precision therapeutic regimens.
