Research progress on the role and mechanisms of butyrate in prevention and treatment of Parkinson's disease
10.11855/j.issn.0577-7402.0729.2025.0611
- VernacularTitle:丁酸在帕金森病防治中的作用及其机制研究进展
- Author:
Dan-Dan WANG
1
;
Bin-Bin REN
Author Information
1. 河南中医药大学康复医学院,河南 郑州 450046;河南中医药大学第一附属医院康复中心,河南 郑州 450000
- Keywords:
butyrate;
Parkinson's disease;
gut microbiota;
short-chain fatty acids;
neuroprotection
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(9):1179-1185
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease(PD)is a common neurodegenerative disease characterized by degeneration of dopaminergic neurons in the substantia nigra,abnormal aggregation of α-synuclein and neuroinflammation.Therapeutic methods including drug intervention have limited efficacy.In recent years,the role of gut microbiota-brain axis in the pathogenesis of PD has received extensive attention.Butyrate acid,as a short-chain fatty acid produced by intestinal microbiota,has been demonstrated to exert certain role in PD prevention and treatment.This review discusses the molecular mechanism of butyrate acid in PD,its potential therapeutic effect and its clinical application in the treatment of PD patients from the perspective of regulating neuroinflammation,mitigating mitochondrial dysfunction,regulating oxidative stress,maintaining intestinal epithelial integrity and blood-brain barrier permeability,in order to provide reference for the research on prevention and treatment of PD.
