Research progress of cell membrane biomimetic nanodrug delivery platform for anti-atherosclerosis
10.11855/j.issn.0577-7402.0916.2025.0314
- VernacularTitle:抗动脉粥样硬化的细胞膜仿生纳米递药平台研究进展
- Author:
Min-Na ZHANG
1
;
Ren-Ming TANG
;
Guang-Hui WANG
Author Information
1. 济宁医学院药学院,山东日照 276826;济宁医学院司法鉴定中心,山东济宁 272013
- Keywords:
atherosclerosis;
cell membrane biomimetic nanodrug delivery platform;
nanomedicine;
targeted treatment
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(8):1029-1037
- CountryChina
- Language:Chinese
-
Abstract:
The cell membrane biomimetic nanodrug delivery platform consists of nanoparticles coated with drug-loaded cell membranes,demonstrating a significant anti-atherosclerosis effect.This platform can identify and bind to atherosclerotic plaques through the homing capabilities of cell membranes.It releases drugs in response to specific environmental triggers,such as reactive oxygen species and shear stress from blood flow in areas affected by atherosclerosis.Furthermore,it inhibits macrophage lipid phagocytosis,thereby reducing foam cell formation,regulating macrophage phenotypes,and decreasing the production of inflammatory factors.Additionally,it accelerates cholesterol dissolution and efflux in atherosclerotic regions,effectively removes high concentrations of reactive oxygen species,and mitigates oxidative stress damage as well as the deposition of oxidized low-density lipoprotein.This review article delves into the functions and mechanisms of cell membrane biomimetic nanodrug delivery platform in combating atherosclerosis,offering fresh insights for targeted atherosclerosis treatment through the lens of nanomedicine.
