Research progress on eosinophilic bronchiectasis:a new inflammatory phenotype
10.11855/j.issn.0577-7402.1949.2025.0428
- VernacularTitle:嗜酸性粒细胞性支气管扩张症:一种新炎症类型的研究进展
- Author:
Lei SHI
1
;
Rong XIA
;
Dan WANG
;
Fang-Wei LI
;
Hai-Dong WEI
Author Information
1. 兰州大学第二医院呼吸科,甘肃兰州 730030
- Keywords:
bronchiectasis;
eosinophilic bronchiectasis;
blood eosinophil count;
inflammatory type
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(8):1022-1028
- CountryChina
- Language:Chinese
-
Abstract:
Non-cystic fibrosis bronchiectasis(referred to as bronchiectasis)is a common chronic airway disease.Neutrophils have traditionally been considered to play a dominant role in the airway inflammation of bronchiectasis.However,it has been discovered that approximately 20％to 30％of bronchiectasis patients exhibited elevated eosinophil counts(Sputum eosinophil ratio＞3％or blood eosinophil count＞300/μl)in their sputum and blood samples,referred to as eosinophilic bronchiectasis(EB).Based on this novel discovery of the inflammatory phenotype,some scholars have advocated treating bronchiectasis as an"inflammatory disease"rather than an"infectious disease"in a novel therapeutic approach.This article reviews the discovery and the latest research advancements of EB,exploring its pathophysiological basis,clinical characteristics,and treatment,with the aim to facilitate the understanding and management of EB.
