Research progress on mechanism and interventional measure of mitochondrial fusion-mediated neural repair after spinal cord injury

VernacularTitle:脊髓损伤后线粒体融合介导的神经修复机制及干预措施研究进展
Author: Yun-Peng LI ¹ ; Ming-Li WU ; Xiao-Dong FENG
Author Information

1. 河南中医药大学康复医学院,河南郑州 450046
Keywords: spinal cord injury; mitochondrial fusion; endogenous neural stem cells; neural circuit remodeling; axon regeneration
From: Medical Journal of Chinese People's Liberation Army 2025;50(8):1015-1021
CountryChina
Language:Chinese
Abstract: Spinal cord injury(SCI)is a serious central nervous system traumatic disease that usually leads to severe neurological dysfunction below the site of injury.Studies have shown that SCI is closely related to oxidative stress,inflammatory responses,and mitochondrial dynamic imbalance.Mitochondrial dysfunction,such as accumulation of mitochondrial DNA damage,depletion of ATP,and impairment of oxidative stress regulation,can lead to dysfunction or death of neurons.Mitochondrial fusion plays a key role in maintaining energy balance and promoting neurological recovery after SCI.This review summarizes the changes in mitochondrial dynamics after SCI and the neuroprotective mechanisms mediated by mitochondrial fusion,with aim to provide new ideas on the treatment of SCI.