Correlation between dynamic contrast-enhanced MRI imaging and clinical pathological features of invasive breast cancer and lymphovascular invasion
10.11855/j.issn.0577-7402.1245.2025.0306
- VernacularTitle:浸润性乳腺癌动态增强MRI影像学特征及临床病理特征与脉管浸润的关系
- Author:
Shi-Qi GUO
1
;
Yu-Jiao XIE
;
Qing-Yang LI
;
Si-Yi CHEN
;
Jia-Hong SUN
;
Zhao-Feng GAO
;
Jun-Qing LIANG
;
Yu-Hui CHEN
;
Bao-Shi BAO
;
Li ZHU
;
Jian-Dong WANG
Author Information
1. 解放军医学院,北京 100853;解放军总医院第一医学中心普通外科,北京 100853
- Keywords:
lymphovascular invasion;
dynamic contrast-enhanced magnetic resonance imaging;
non-mass enhancement;
molecular subtypes;
invasive breast cancer
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(7):847-854
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)and clinical pathological features of invasive breast cancer and lymphovascular invasion(LVI).Methods Imaging and clinical pathological data were retrospectively collected from 508 patients with invasive breast cancer who underwent breast DCE-MRI at the First Medical Center of Chinese PLA General Hospital from January 2019 to August 2021.Patients were divided into the LVI-positive(LVI+)group(n=79)and LVI-negative(LVI-)group(n=429)based on postoperative pathological results.Univariate and multivariate logistic regression analyses were used to identify risk factors for LVI.Results Compared with LVI-group,LVI+group had a higher proportion of patients aged<45 years(44.3%vs.27.0%,P=0.002),non-mass-like enhancement(NME)(31.7%vs.17.7%,P=0.004),Ki-67 expression rate(40.0%vs.30.0%,P<0.001),high Ki-67 expression(94.9%vs.78.1%,P=0.001),Luminal B subtype(76.0%vs.60.1%,P=0.008),and positive axillary lymph nodes rate(72.2%vs.31.5%,P<0.001),while the proportion of Luminal A subtype was lower(2.5%vs.21.5%,P<0.001).Univariate and multivariate logistic regression analyses showed that age≥45 years(OR=0.468,95%CI 0.280-0.783,P=0.004)was an independent protective factor for LVI,while NME(OR=1.987,95%CI 1.126-3.444,P=0.016)was an independent risk factor.Compared with Luminal A subtype,patients with Luminal B subtype(OR=10.482,95%CI 3.164-64.923,P=0.001),HER-2 overexpression subtype(OR=11.571,95%CI 2.755-79.341,P=0.003)and triple-negative subtypes(OR=8.433,95%CI 1.985-57.908,P=0.009)had a higher risk of LVI.Conclusions Age≥45 years is an independent protective factor for LVI,while NME is an independent risk factor.Among molecular subtypes,patients with Luminal B,HER-2 overexpression and triple-negative subtypes have a higher risk of LVI compared with the Luminal A subtype.
