Research progress on the role of peripheral blood cells in deep vein thrombosis

VernacularTitle:外周血细胞在深静脉血栓形成中的作用研究进展
Author: Zhen AN ¹ ; Xue QI ; Jun ZHANG ; Yue ZHANG
Author Information

1. 山东中医药大学附属医院周围血管病科,山东济南 250014
Keywords: peripheral blood cells; neutrophils; monocytes; lymphocytes; deep venous thrombosis
From: Medical Journal of Chinese People's Liberation Army 2025;50(6):771-777
CountryChina
Language:Chinese
Abstract: Deep venous thrombosis(DVT)has become one of the important diseases threatening human life and health due to its high incidence and mortality rates.The three generally recognized major risk factors for thrombosis are blood flow stasis,vascular wall injury,and hypercoagulability.However,the specific cellular mechanisms remain incompletely understood.In recent years,with the in-depth study of the pathogenesis of DVT,accumulating evidence has demonstrated that dysfunctional peripheral blood cells play an indispensable role in its pathogenesis.This review summarizes the impacts of neutrophils,monocytes,lymphocytes,platelets,and red blood cells in peripheral blood on the occurrence and development of DVT,and explores the potential mechanisms of these impacts,aiming to provide new non-anticoagulation targets for the prevention and treatment of DVT.