Assessment of causality between cathepsins and thyroid cancer:a two-sample Mendelian randomization
10.11855/j.issn.0577-7402.0450.2024.1014
- VernacularTitle:组织蛋白酶与甲状腺癌的因果关系:双样本孟德尔随机化分析
- Author:
Wen-Jing LIAN
1
;
Xiao-Hui SUN
;
Shuang LIANG
;
Yi-Hua SUN
;
Zi-Yuan SUN
Author Information
1. 山东中医药大学第一临床医学院,山东 济南 250014
- Keywords:
thyroid cancer;
cathepsin;
Mendelian randomization;
biomarkers
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(6):709-715
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the causal relationship between cathepsin(CTS)and thyroid cancer by using Mendelian randomization(MR).Methods Aggregate data for CTS GWAS was obtained from the IEU Open Genome-wide Association Study(GWAS)database(https://gwas.mrcieu.ac.uk/),and thyroid cancer GWAS data was obtained from the EBI database(https://www.ebi.ac.uk/).Five different MR analysis methods were utilized,with the inverse variance-weighted method(IVW)as the main approach,complemented by the weighted median method,MR-Egger regression,simple mode method and weighted majority method.These methods were employed to analyze the relationship between 9 CTS genes and thyroid cancer through 9 double-sample analyses.MR-Egger intercept,MR-PRESSO for gene pleiotropy detection,Cochran Q test,and leave-one-out method were applied to assess pleiotropy and sensitivity,followed by reverse MR analysis.Results MR analysis showed that elevated level of CTS B was positively correlated with the risk of thyroid cancer(IVW OR=1.60,95%CI 1.12-2.30,P=0.01),while elevated CTS O level was negatively correlated with the risk of thyroid cancer(IVW OR=0.65,95%CI 0.45-0.95,P=0.02).Reverse MR analysis revealed no significant causal relationship between thyroid cancer and CTS B and CTS O(P>0.05).Conclusion CTS B may promote the development of thyroid cancer,whereas CTS O may inhibit its progression.
