Research progress on the spatial heterogeneity of PD-L1
10.11855/j.issn.0577-7402.0399.2024.1105
- VernacularTitle:PD-L1的空间异质性研究进展
- Author:
Li-Yuan RU
1
;
Wei GUO
;
Wen-Dan YU
Author Information
1. 大连医科大学肿瘤干细胞研究院,辽宁 大连 116044
- Keywords:
tumor cells;
programmed death ligand-1;
spatial heterogeneity;
exosomes
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(6):679-687
- CountryChina
- Language:Chinese
-
Abstract:
Programmed death ligand-1(PD-L1),which is expressed on the surface of tumor cells,can bind to programmed death receptor-1(PD-1)on T cells.The interaction between PD-1 and PD-L1 can activate negative regulatory signal of T cells and inhibit their activation and proliferation,thus promoting tumor immune escape.PD-L1 is mainly expressed on the tumor cell membrane,but is also distributed in the nucleus,cytoplasm,and exosomes.Different spatial distribution of PD-L1 has different effects on tumors,among which the dynamic transformation and spatial heterogeneity expression of PD-L1 in tumors is the main reason for the unsatisfactory efficacy of PD-L1 antibodies.This article aims to introduce the spatial heterogeneity of PD-L1,and review the research progress on PD-L1 dynamic transformation in tumor cells,so as to provide new ideas for antitumor therapy based on PD-L1 antibody.
