Research progress on the role of NF-κB signaling pathway in drug resistance mechanisms of pancreatic cancer
10.11855/j.issn.0577-7402.1474.2025.0327
- VernacularTitle:NF-κB信号通路在胰腺癌耐药机制中的研究进展
- Author:
Ya-Ting SHU
1
;
Jing-Wen SHI
;
Fan LEI
;
Zhao CUI
;
Mei-Fang LIU
;
Mei-Yu PENG
Author Information
1. 山东省高等学校免疫微环境与炎症性疾病研究特色实验室/山东第二医科大学免疫学实验室,山东 潍坊 261053
- Keywords:
pancreatic cancer;
nuclear factor-κB;
resistance;
chemotherapy;
immunotherapy
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(6):665-671
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer is characterized by significant drug resistance,and despite continuous advancements in treatment regimens,the 5-year survival rate of patients remains low.The nuclear factor-κB(NF-κB)signaling pathway,frequently mutated in tumors,has been identified as a critical factor in triggering drug resistance.Multiple studies have demonstrated that strategies targeting NF-κB signaling transduction exhibit promising outcomes in pancreatic cancer treatment.Therefore,exploring the relationship between the NF-κB signaling pathway and drug resistance in pancreatic cancer has become a research hotspot in pancreatic cancer treatment.This review summarizes recent advances in the relationship between NF-κB signaling pathway and tumor drug resistance,as well as its role in pancreatic cancer treatment.Specifically,the mechanisms by which the NF-κB signaling pathway mediates drug resistance in pancreatic cancer are elaborated from two perspectives:chemotherapy and immunotherapy,aiming to provide insights for pancreatic cancer treatment and future research.
