Advances in research of pathophysiological mechanisms and diagnosis of Alzheimer's disease

VernacularTitle:阿尔茨海默病病理生理机制及其诊断研究进展
Author: Ya-Nan WANG ¹ ; Ling REN ; Wei HAN ; Bin SUN
Author Information

1. 首都医科大学电力教学医院(国家电网公司北京电力医院)核医学科,北京 100073
Keywords: Alzheimer's disease; cognitive impairment; imaging diagnosis; biomarkers
From: Medical Journal of Chinese People's Liberation Army 2025;50(5):632-640
CountryChina
Language:Chinese
Abstract: Alzheimer's disease(AD),a major cause of dementia,is a common neurodegenerative disease,beginning with memory loss and difficulties with thinking,language and problem-solving skills.Intensification of population aging and the increasing incidence of AD have imposed a heavy burden on healthcare systems.Currently,the main pathological explanation remains the excessive accumulation of β-amyloid plaques,formation of neurofibrillary tangles and neuronal loss,but the true etiology and pathogenesis of AD remain unknown.The advances of research in AD,with respect to genetics,pathophysiological mechanism,imaging diagnosis and laboratory diagnosis,are reviewed in this article,aiming to provide references for relevant research and potential clinical applications.