Research progress on inflammatory status and targeted microbiota intervention strategies in chronic kidney disease
10.11855/j.issn.0577-7402.1378.2024.1218
- VernacularTitle:慢性肾脏病炎症状态及靶向菌群干预策略的研究进展
- Author:
Shao-Jie KOU
1
;
Xin LI
;
Fen-Ping LI
;
Xiao-Yong YU
;
Xiao-Lin BAI
Author Information
1. 陕西省中医医院肝病科,陕西 西安 710003
- Keywords:
chronic kidney disease;
inflammation;
probiotics;
prebiotics;
synbiotics
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(5):619-631
- CountryChina
- Language:Chinese
-
Abstract:
The inflammatory status in patients with chronic kidney disease(CKD)is closely associated with cardiovascular events,infections,and other complications,and is a powerful indicator for prognosis assessment.The core view of the"gut-kidney axis"theory reveals the relationship among inflammatory state,microbiota dysbiosis,and deterioration of renal function.The microbiota alters the microenvironment through structural changes and metabolites with different properties,subsequently leading to microbiota translocation,inducing inflammatory lesions,and damaging the kidneys.Recent studies have proposed that targeted microbiota intervention strategies such as probiotics,prebiotics,and synbiotics can modulate the microbiota structure,regulate the microenvironment,relieve renal inflammation,and affect the progression of renal disease,representing a potentially promising research direction in the future.This review discusses the characteristics of how intestinal microbiota influence the inflammatory status in CKD,focusing on the research progress of targeted microbiota intervention,aiming to discuss the effectiveness and scientific basis of these strategies,providing a foundation for the treatment of CKD and the expansion of targeted microbiota research,as well as offering references for the clinical application of probiotics,prebiotics,and synbiotics.
