Research progress of transcriptomics sequencing technology in evaluating human endometrial receptivity
10.11855/j.issn.0577-7402.1475.2024.0731
- VernacularTitle:转录组测序技术在人子宫内膜容受性研究中的应用进展
- Author:
Li-Na MA
1
;
Hai-Ning QI
;
Mei LIU
;
Yang LIU
;
Hang GE
;
Feng-Juan LU
;
Xiao-Ke WU
;
Ying QIN
Author Information
1. 山东中医药大学附属医院产科,山东 济南 250014;山东中医药大学博士后流动站,山东 济南 250000
- Keywords:
endometrium;
RNA sequencing;
embryo transfer;
endometrial receptivity
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(5):607-611
- CountryChina
- Language:Chinese
-
Abstract:
Good endometrial receptivity is an essential factor for embryo implantation,and gene expression in endometrial tissue during the window of implantation(WOI)is closely related to receptivity.Transcriptome sequencing technology enables the identification of gene expression profiles of endometrium during different menstrual phases,as well as microRNAs and long-chain non-coding RNA sequences involved in regulating gene expression.Combining this technology with bioinformatics analysis provides a better understanding of specific gene expression during the receptive period and offers technical support for studying its regulatory mechanism.Moreover,gene expression profiles of the endometrium during different menstrual phases hold significant clinical application value for accurately assessing endometrium receptivity in infertility patients and those with repeated implantation failure,thereby guiding individualized embryo transfer strategies.This review summarizes the progress of transcriptome sequencing in evaluating human endometrial receptivity and discusses future research directions.This review aims to understand the complex molecular mechanisms of endometrial receptivity formation and regulation from the transcriptional level,in order to improve the implantation rate of embryos in assisted reproductive technology and reduce the abortion rate.
