Research progress on AMPK signaling pathway in the regulation and treatment of spinal cord injury

VernacularTitle:AMPK信号通路在脊髓损伤调控及治疗中的作用研究进展
Author: Zhi-Lan ZHANG ¹ ; Xiao-Meng HUANG ; Wen-Ya SHANG ; Jing HUANG ; Hui-Lin WEI ; Bing LI ; Ya-Feng REN
Author Information

1. 郑州大学第五附属医院儿童康复医学科,河南郑州 450015
Keywords: spinal cord injury; AMP-activated protein kinase; pathological mechanism; neuroinflammation; axon regeneration
From: Medical Journal of Chinese People's Liberation Army 2025;50(4):495-503
CountryChina
Language:Chinese
Abstract: Spinal cord injury(SCI)is a central nervous system disease with high morbidity and disability rates,bringing serious economic and psychological burdens to families and society worldwide.AMP-activated protein kinase(AMPK)is an important sensor in the energy metabolism process in living organisms,which plays a central role in maintaining energy balance.It is currently considered a key target for the prevention and treatment of multiple diseases.Studies have shown that AMPK signaling can regulate autophagy,neuroinflammation,oxidative stress,mitochondrial function and other processes after SCI,thus affecting the pathological process of SCI.This review summarizes the research progress on AMPK signaling pathway involved in the regulation of SCI,in order to provide new ideas for the treatment and drug development of SCI.