Research progress on correlation of non-steroidal anti-inflammatory drugs and bone stress injury
10.11855/j.issn.0577-7402.0447.2024.0730
- VernacularTitle:非甾体抗炎药与应力性骨损伤的相关研究进展
- Author:
Ning QIANG
1
;
Jin WANG
;
Jian YU
;
Jin-Fang XU
;
Ming-Xin WANG
;
Chen-Hui DONG
;
Shen-Song LI
;
Jin ZHAO
;
Chun-Bao LI
Author Information
1. 解放军联勤保障部队第940医院运动医学科,甘肃 兰州 730050;西北民族大学医学部,甘肃 兰州 730030;宁夏永宁县人民医院骨科,宁夏 银川 750100
- Keywords:
non-steroidal anti-inflammatory drugs;
bone stress injuries;
bone metabolism;
prostaglandin;
osteocyte
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(3):341-350
- CountryChina
- Language:Chinese
-
Abstract:
Non-steroidal anti-inflammatory drugs(NSAIDs),commonly utilized analgesics,are extensively employed for managing pain associated with musculoskeletal disorders or injuries.Recent clinical studies have demonstrated a heightened risk of bone stress injuries(BSI)in soldiers and athletes,particularly during high-intensity training,due to NSAID usage.Furthermore,the impact of NSAIDs on fracture healing is well-documented;however,the precise mechanism by which their use during training contributes to an increased incidence of stress bone injuries remains unclear.This article aims to summarize potential mechanisms through an extensive review of domestic and international literature in order to standardize the utilization and clinical management of NSAIDs,optimize pain management strategies,and prevent stress bone injuries or fractures in specific populations such as soldiers and elite athletes.
