Research progress of the relationship between gut microbiota and systemic lupus erythematosus
10.11855/j.issn.0577-7402.0941.2025.0121
- VernacularTitle:肠道菌群与系统性红斑狼疮关系的研究进展
- Author:
Lin-Feng GUO
1
;
Bin ZHANG
;
Hong-Zhi WANG
;
Ming-Feng YANG
Author Information
1. 浙江中医药大学嘉兴大学联合培养基地,浙江 杭州 310053
- Keywords:
systemic lupus erythematosus;
16S DNA;
metagene;
intestinal flora
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(3):284-291
- CountryChina
- Language:Chinese
-
Abstract:
Systemic lupus erythematosus(SLE)is a chronic diffuse connective tissue disease characterized by abnormal activation of the immune system,which attacks the body's tissues.It has a complex course and its pathological basis is vasculitis.In recent years,research on the relationship between SLE and the gut microbiota has increased significantly,but how to regulate the gut microbiota for the treatment of SLE remains unclear.Studies have found that the intestinal microbiota of SLE patients differs from that of healthy people in terms of Firmicutes,Bacteroidetes,Actinomycetes,and Proteobacteria,etc.,and this has been verified in animal experiments.In this review,the changes of intestinal microbiota in SLE patients and their association with the pathogenesis and progression of the disease are systematically reviewed,aiming to provide new insights into the treatment of SLE.
