The research progress on the correlation between gut microbiota and Graves'ophthalmopathy
10.11855/j.issn.0577-7402.0931.2024.0328
- VernacularTitle:肠道菌群与格雷夫斯眼病相关性的研究进展
- Author:
Yue-Ying LI
1
;
Shan-Si YUAN
;
Yang WANG
;
Kai-Jun LI
Author Information
1. 广西医科大学第一附属医院眼科,广西 南宁 530021
- Keywords:
Graves'ophthalmopathy;
gut microbiota;
pathogenesis;
treatment
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(3):269-276
- CountryChina
- Language:Chinese
-
Abstract:
Graves'ophthalmopathy(GO)is a specific autoimmune disease occurring in orbital tissues and is closely related to hyperthyroidism caused by Graves'disease(GD).Its disabling and disfiguring features significantly impact the quality of life of patients.The exact mechanism of GO still remains to be fully elucidated.In recent years,gene sequencing and medical microbiology studies have shown that changes in the gut microbiota may play a role in the development and progression of GO,with gut dysbiosis altering immune system regulatory signals and causing immune damage to organs.Clarifying the correlation between gut microbiota and GO helps to understand the disease's pathogenic mechanism and provides a theoretical basis for the diagnosis and treatment of GO.This review summarizes the impact of gut microbiota dysbiosis in the pathogenesis of GO and promising therapeutic approaches,including research progress in aspects such as gut microbiota experiments,case studies,pathogenesis,and treatment strategies.
