Research progress on the molecular mechanisms of PANoptosis and its role in some diseases
10.11855/j.issn.0577-7402.1503.2024.0529
- VernacularTitle:泛凋亡的分子机制及其在部分疾病中的作用研究进展
- Author:
Yu-Qi SONG
1
;
Wen-Ming YANG
;
Tao-Hua WEI
;
Yu-Long YANG
;
Zi-Long LI
Author Information
1. 安徽中医药大学第一临床医学院,安徽 合肥 230031
- Keywords:
PANoptosis;
cell death;
illness;
molecular mechanism
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(2):221-231
- CountryChina
- Language:Chinese
-
Abstract:
Cellular death in the body can occur through different processes,including apoptosis,pyroptosis and necrotic apoptosis,etc.PANoptosis is a newly discovered form of inflammatory cell death in recent years.It can be triggered by various stimulating factors and integrates multiple components that can induce cell death to assemble into various types of macromolecular complexes-PANoptosome,which then mediates cell death.Given the impact of PANoptosis on the entire disease spectrum,promoting or inhibiting its occurrence process may prevent the development of various diseases.The review summarizes the research progress on the occurrence mechanism of PANoptosis and its role in some diseases,and explores the crosstalk among multiple programmed cell death pathways,aiming to provide new ideas for the treatment of related diseases.
