Constructive elements and applications of sebaceous gland organoids
10.11855/j.issn.0577-7402.1157.2024.0528
- VernacularTitle:皮脂腺类器官的构建要素与应用
- Author:
Lu WU
1
;
Biao LIU
;
Li-Xin WENG
Author Information
1. 内蒙古医科大学基础医学院,内蒙古 呼和浩特 010110;包头医学院基础医学与法学学院生理教研室,内蒙古 包头 014040
- Keywords:
skin;
sebaceous gland;
organoid;
application
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(1):112-120
- CountryChina
- Language:Chinese
-
Abstract:
Sebaceous glands are vital appendages of the skin,primarily functioning in the secretion of a variety of lipid substances.These lipid substances play crucial physiological roles in the body,such as participating in body temperature regulation,maintaining skin homeostasis,and modulating the immune system.Abnormalities in the function of sebaceous glands can lead to a range of skin disorders,with acne being the most common one.Acne arises from the overproduction of sebum by sebaceous gland,leading to hair follicle blockage,bacterial infection,and inflammation response.Additionally,sebaceous gland carcinoma is a rare but severe malignant tumor of the skin,and its exact mechanisms are not fully understood.Organoids are closely resemble in vivo counterparts in terms of cell types,spatial structure,and function.Sebaceous gland organoids serve as an ideal platform for studying sebaceous glands and their associated diseases.This review summarizes the structure,function,homeostasis of sebaceous glands,as well as the construction and applications of sebaceous gland organoids,aiming to provide reference for research on the pathogenesis and treatment of sebaceous gland related diseases.
