Advances in nanoparticle drug delivery systems for intervertebral disc degeneration
10.11855/j.issn.0577-7402.1125.2024.0407
- VernacularTitle:纳米颗粒药物递送系统在椎间盘退变中的应用研究进展
- Author:
Bao-Lin ZHANG
1
;
Xue-Xue LI
;
Zhi-Zhong SHANG
;
Ming-Chuan WANG
;
Xin WANG
Author Information
1. 兰州大学第一临床医学院,甘肃 兰州 730000
- Keywords:
intervertebral disc degeneration;
nanoparticles;
drug delivery;
carrier;
targeting
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(1):101-111
- CountryChina
- Language:Chinese
-
Abstract:
Intervertebral disc degeneration(IDD)is a prevalent clinical degenerative disease that currently can only be treated through conservative and surgical treatments,which only alleviate symptoms and are not significantly effective.In recent years,nanoparticles have been widely studied in the biomedical field due to their biodegradability,biocompatibility,extended body circulation,sustained and controlled release,and precise drug targeting.Nanoparticle drug delivery systems have the potential to deliver a range of therapeutic agents including proteins,drugs,genes,and cells,thereby promoting tissue and cell repair and regeneration,which offers hope for IDD treatment.However,there are still challenges in translating experimental data into practical therapies applicable to humans.This review summarizes recent research progress on drug delivery systems for IDD treatment based on nanoparticles and provides insights and prospects for the challenges faced by nanoparticles,aiming to provide a reference for the clinical translation of nanoparticle-based treatment for IDD.
