Golgi apparatus stress and its role in infectious diseases:a review of recent advances
10.11855/j.issn.0577-7402.0654.2024.0918
- VernacularTitle:高尔基体应激及其在感染性疾病中的作用研究进展
- Author:
Qi FAN
1
;
Yao WU
;
Xiao-Mei ZHU
;
Yong-Ming YAO
Author Information
1. 温州医科大学附属第一医院急诊医学中心,浙江 温州 325015;解放军总医院医学创新研究部/第四医学中心,北京 100853
- Keywords:
Golgi apparatus;
Golgi apparatus stress;
Golgi apparatus stress response;
infectious diseases
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(1):83-91
- CountryChina
- Language:Chinese
-
Abstract:
The Golgi apparatus(GA),an essential membrane organelle in eukaryotes positioned between the endoplasmic reticulum and the plasma membrane,is responsible for transporting and modifying proteins and lipids generated by the endoplasmic reticulum.The homeostasis of the endoplasmic reticulum and GA plays a crucial role in regulating cellular life.When GA is unable to bear the load of protein or lipid processing and transportation,it enters a state of stress.Cells sense this and activate Golgi-related quality control mechanisms.By regulating the structure and function of GA,it provides important protection for the cell or induces programmed cell death,known as the GA stress response.Understanding the mechanisms and outcomes of cellular GA stress is of great significance for exploring Golgi dynamics and its impact on human diseases.This review summarizes the structure and function of GA under physiological conditions,the phenomenon of GA stress under pathological conditions,and the role of GA in infectious diseases,aiming to provide a basis for the clinical study of new strategies for the prevention and treatment of infectious diseases.
