Predictive value of dose-surface histogram for acute radiation proctitis in prostate cancer patients following radiotherapy
10.11855/j.issn.0577-7402.1627.2024.0701
- VernacularTitle:剂量表面积直方图对前列腺癌患者放射治疗后急性直肠炎的预测价值
- Author:
Xin ZHAO
1
;
Mei-Liu YANG
;
Xiao-Hui HAO
;
Tian-Xiong WEI
;
Qi ZHANG
;
Hao-Yu CHANG
;
Xiu-Xia WU
Author Information
1. 河北北方学院附属第一医院放疗科,河北 张家口 075000
- Keywords:
dose and surface histogram;
prostate cancer;
rectal toxicity;
forecast
- From:
Medical Journal of Chinese People's Liberation Army
2025;50(1):44-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the predictive value of dose-surface histogram(DSH)for radiation proctitis(RP)in prostate cancer(PCa)patients undergoing radiotherapy.Methods This prospective randomized controlled clinical trial included 380 PCa patients who underwent image-guided radiotherapy in the First Affiliated Hospital of Hebei Northern University from January 2018 to January 2023.Patients were randomly divided into observation group(n=200)and control group(n=180).The rectal dose distribution of patients in the two groups was evaluated by using DSH and dose-volume histogram(DVH),respectively.The receiver operating characteristic(ROC)curve was utilized to evaluate the predictive value of DSH for acute RP,with DVH serving as a reference.Results The difference was not statistically significant in clinical information such as age,KPS score,and body mass index(BMI)between the observation and control groups(P＞0.05),as well as in acute RP incidence(P＞0.05).There were significant differences in S40 and V40,S50 and V50,S60 and V60,S70 and V70,and S78 and V78 between the two groups(P＜0.05).S40,S50,V40,and V50 showed low efficacy(P＜0.001)in predicting acute RP at each level,with AUC≤0.700.S60 and V60 showed moderate efficacy(P＜0.001)in predicting acute RP at each level,with AUC 0.700-0.900.S70,S78,V70 and V78 showed high efficacy(P＜0.001)in predicting acute RP at each level,with AUC＞0.900.Conclusions The predictive value of DSH for rectal toxicity in patients with PCa is basically consistent with that of DVH.It is expected to become a novel and valuable tool for evaluating radiotherapy plans in the future.
