Research progress on vascular endothelial dysfunction and its biomarkers in cerebral small vessel disease

VernacularTitle:脑小血管病血管内皮功能障碍及其生物标志物研究进展
Author: Zhao-Ze ZHANG ¹ ; Hao JIAO ; Ying CHEN ; Xiang-Yang GUO ; Zheng-Qian LI
Author Information

1. 北京大学第三医院麻醉科,北京 100191
Keywords: cerebral small-vessel disease; blood-brain barrier; white matter hyperintensities; endothelial cell dysfunction; biomarkers
From: Medical Journal of Chinese People's Liberation Army 2024;49(12):1444-1451
CountryChina
Language:Chinese
Abstract: Cerebral small vessel disease(CSVD)is a group of local brain tissue lesions caused by abnormal small vessels in the brain due to different etiologies.The pathogenesis of CSVD is not yet fully understood,and its diagnosis currently mainly relies on clinical imaging examinations.Endothelial cells(ECs)in cerebral blood vessels can play an important role in maintaining the structure and function of the blood-brain barrier,regulating cerebral blood flow,and mediating neurovascular coupling.In recent years,studies have shown that ECs dysfunction plays an important triggering and mediating role in the pathological changes of CSVD,and may even be a key initiating link in its pathogenesis.Moreover,biomarkers related to ECs dysfunction are associated with the severity of CSVD.The review summarizes the role of ECs dysfunction in the pathogenesis of CSVD,and the research progress of related biomarkers,aiming to provide references for the diagnosis and treatment of CSVD.