Relationship of the onset of fatigue symptoms and pulmonary artery pressure in people acutely rushing into high altitude areas
10.11855/j.issn.0577-7402.2020.12.06
- VernacularTitle:急进高原健康青年男性人群疲劳症状发生情况及其与肺动脉压力的关系
- Author:
Jing-Du TIAN
1
;
Chuan LIU
;
Jie YANG
;
Xu-Bin GAO
;
Ji-Hang ZHANG
;
Xiao-Hui ZHAO
;
Lan HUANG
Author Information
1. 陆军军医大学第二附属医院心内科,重庆 400037
- Keywords:
high altitude;
fatigue;
pulmonary artery pressure;
risk factor
- From:
Medical Journal of Chinese People's Liberation Army
2020;45(12):1248-1253
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the incidence of fatigue symptoms and the relationship with pulmonary artery pressure in healthy people who acutely rush into high altitude(HA)areas.Methods A hundred and thirty-six healthy subjects(young men)were recruited during June to July 2013,and transported from Chongqing C.(asl.400 m)to Litang Co.(asl.4100 m)by bus.The physiological parameters of subjects were collected before and after entering the plateau,the heart function and the hemodynamic indexes of pulmonary circulation were detected by echocardiography.The subjects were divided into fatigue+group(n=78)and fatigue-group(n=58)according to their degree of fatigue evaluated with Fatigue Assessment Scale.The changes of the above indicators were compared before and after entering the plateau and between the two groups of subjects.Logistic regression analysis was performed to screen the related risk factors of plateau fatigue.Results Following acute high altitude exposure,the mean pulmonary arterial pressure(mPAP),pulmonary artery systolic pressure(sPAP)and pulmonary vascular resistance(PVR)in subjects increased obviously.Compared with fatigue-group,the mPAP,sPAP and PVR increased significantly in fatigue+group[17.9 mmHg vs.20.6 mmHg;26.1 mmHg vs.30.4 mmHg;and 4.41 Woods vs.5.56 Woods],and more larger right ventricular end diastolic area(RVEDA)[(22.0±3.8)cm2 vs.(20.5±3.6)cm2],right ventricular end systolic area(RVESA)[(13.1±2.7)cm2 vs.(12.1±2.3)cm2]and transverse diameter of right ventricular base[(3.92±0.45)cm vs.(3.72±0.41)cm]were in fatigue+group than those in fatigue-group with statistical significance(P<0.05).Logistic regression analysis indicated that increased mPAP was an independent risk factor for the onset of high altitude fatigue(OR=1.130,95%CI 1.034-1.235,P=0.007).Conclusion Acutely rushing into the plateau may lead to the incidence of fatigue symptoms and increased pulmonary artery pressure,which is the independent risk factor for the occurrence of fatigue symptoms.
