Comparison of biological characteristics of natural killer cells from different sources
10.16352/j.issn.1001-6325.2025.12.1668
- VernacularTitle:不同来源自然杀伤细胞的生物学特性比较
- Author:
Junxia WANG
1
;
Zaidong XIE
;
Chunlei PAN
;
Feng WU
;
Dingsheng LIU
;
Jianrong ZHU
;
Chunhua ZHAO
Author Information
1. 领航干细胞再生医学工程有限公司,江苏 南通 226000
- Keywords:
natural killer cells;
chimeric antigen receptor-NK cells(CAR-NK cells);
tumor;
immunotherapy;
carrier delivery
- From:
Basic & Clinical Medicine
2025;45(12):1668-1674
- CountryChina
- Language:Chinese
-
Abstract:
Natural killer cells(NK)are important innate immune cells that do not require prior antigen exposure and can directly recognize and attack virus-infected cells and tumor cells.The activation and effector functions of NK cells are regulated by a balance of signals delivered through their surface activating receptors and inhibitory re-ceptors,which bind to ligands on target cells to achieve cytotoxicity via"induced self"and"missing self"recogni-tion models.The killing mechanisms of NK cells primarily include release of cytotoxic granules such as perforin and granzymes to induce target cell lysis,death receptor-mediated apoptosis,secretion of various cytokines,chemokines and growth factors to coordinate with other immune cells in killing tumor cells,thereby generating secondary im-mune responses and antibody-dependent cellular cytotoxicity(ADCC).
