Advances in synergistic therapies targeting metabolic mechanisms and the immune microenvironment in breast cancer
10.16352/j.issn.1001-6325.2025.12.1662
- VernacularTitle:乳腺癌代谢机制与免疫微环境靶向的协同治疗进展
- Author:
Yanchi ZHANG
1
;
Junqi SHI
;
Yijun ZHANG
;
Jiawen DUAN
;
Jinyu LIU
;
Liyan ZHANG
;
Wanping LIANG
Author Information
1. 河北北方学院附属第一医院 乳腺外科,河北 张家口 075000
- Keywords:
breast cancer;
metabolic reprogramming;
tumor microenvironment;
tumor metabolism;
immune suppression
- From:
Basic & Clinical Medicine
2025;45(12):1662-1667
- CountryChina
- Language:Chinese
-
Abstract:
This review systematically summarizes the unique metabolic mechanisms of breast cancer,their interac-tions with the tumor microenvironment(TME),and the latest advances in targeted therapies.The interplay between metabolic reprogramming and the TME underpins malignant progression and therapeutic resistance.Breast cancer cells reshape energy supply through the Warburg effect,aberrant fatty acid synthesis,and amino acid metabolism,while immune cells,fibroblasts,and the acidic milieu within the TME promote immune evasion and drug resistance via metabolic coupling.Although traditional strategies targeting key metabolic enzymes remain valuable,they are often insufficient to overcome metabolic adaptability.In recent years,combined metabolic and immunotherapeutic approaches have emerged as promising strategies:by reducing lactate accumulation,restoring T-cell function,and reprogramming tumor-associated macrophages and cancer-associated fibroblasts,these therapies can remodel the immunosuppressive microenvironment and enhance immunotherapy efficacy.The application of metabolomics and single-cell sequencing further elucidates breast cancer heterogeneity,providing a basis for individualized precision treatment.Future challenges include deciphering resistance mechanisms,developing highly selective metabolic in-hibitors,and designing integrated multi-omics-based therapeutic regimens.
