Role of SP1 phosphorylation in development of tumor
10.16352/j.issn.1001-6325.2025.12.1657
- VernacularTitle:SP1磷酸化在肿瘤发生发展中的作用
- Author:
Chengpu XIAO
1
;
Xutao SUN
;
Yunjia SONG
;
Ying XIE
;
Deyou JIANG
Author Information
1. 黑龙江中医药大学附属第一医院,黑龙江 哈尔滨 150040
- Keywords:
specificity protein 1;
phosphorylation;
protein kinase
- From:
Basic & Clinical Medicine
2025;45(12):1657-1661
- CountryChina
- Language:Chinese
-
Abstract:
Phosphorylation is a common post-translational modification of specific protein 1(SP1),which can affect its transcriptional activity and DNA-binding stability by altering the structure of SP1.Phosphorylation of SP1 can promote telomere maintenance,immune escape,and production of vascular endothelial growth factor in cancer cells,promote tumor invasion and metastasis,and increase drug resistance to chemotherapy.
