Clinical research progress on mesenchymal stem cells in the treatment of chronic limb-threatening ischemia
10.16352/j.issn.1001-6325.2025.11.1511
- VernacularTitle:间充质干细胞治疗慢性肢体威胁性缺血的临床研究进展
- Author:
Zhiqiang LIU
1
;
Xufang GU
;
Aixin NI
;
Shanshan FAN
Author Information
1. 天津中医药大学第二附属医院科学技术科,天津 300250
- Keywords:
mesenchymal stem cells;
chronic limb-threatening ischemia;
cell therapy;
angiogenesis;
clinical research
- From:
Basic & Clinical Medicine
2025;45(11):1511-1515
- CountryChina
- Language:Chinese
-
Abstract:
Chronic limb-threatening ischemia(CLTI)is a serious peripheral arterial disease(PAD)characterized by reduced blood flow in the limbs,resulting in tissue damage and dysfunction.Mesenchymal stem cells(MSCs)have become a research hotspot in the field of CLTI treatment in recent years due to their unique regenerative ability and immunomodulatory properties.In the environment of hypoxia and tissue injury,MSCs can promote angiogenesis,reduce inflammation and promote tissue repair by secreting cytokines,cell differentiation and inter-cellular signal transduction,so as to improve the symptoms and prognosis of patients with CLTI,showing a broad clinical application prospect.
