Progress of PANoptosis in age-related diseases
10.16352/j.issn.1001-6325.2025.11.1506
- VernacularTitle:泛凋亡在年龄相关性疾病中的研究进展
- Author:
Yue ZHANG
1
;
Junying WANG
Author Information
1. 大连大学附属新华医院耳鼻咽喉科,辽宁大连 116021
- Keywords:
cell death;
PANoptosis;
age-related
- From:
Basic & Clinical Medicine
2025;45(11):1506-1510
- CountryChina
- Language:Chinese
-
Abstract:
PANoptosis is a novel mode of cell death that intelligently initiates signaling pathways by forming PANoptosome.It can promote the development of retinopathy and nephropathy by regulating the inflammatory response and cell death triggered by hyperglycemia.It activates inflammasome release and plays a role in Alzheimer's disease(AD)and osteoarthritis.Similarly,PANoptosis can promote cochlear aging by damaging mitochondria,changing immune response and inducing inflammatory response,aiming to provide new thera-peutic ideas for the disease.
