Progress on poly(C)-binding protein 1 in ferroptosis
10.16352/j.issn.1001-6325.2025.11.1501
- VernacularTitle:Poly(C)-结合蛋白1在铁死亡中的研究进展
- Author:
Tianna LIU
1
;
Yang LI
;
Yudi DENG
;
Fuju WU
Author Information
1. 吉林大学白求恩第二医院妇产科,吉林长春 130041
- Keywords:
poly(C)-binding protein 1(PCBP1);
ferroptosis;
ferritin;
lipid peroxidation
- From:
Basic & Clinical Medicine
2025;45(11):1501-1505
- CountryChina
- Language:Chinese
-
Abstract:
Poly(C)-binding protein 1(PCBP1)is a multifunctional RNA-binding protein involved in a series of processes such as gene transcription,selective modification,translation and regulation of iron metabolism.This pa-per explores the pathway through which PCBP1 inhibits ferroptosis during the research on PCBP1-related diseases,such as bladder cancer and head and neck cancer.PCBP1 can reduce the intracellular ferrous iron content to inhib-it ferroptosis through the mechanisms like inhibiting ferritinophagy,promoting the transfer of iron ions to ferritin or iron-dependent enzymes,stabilizing the labile iron pool within cells and facilitating the formation of[2Fe-2S]clus-ters.PCBP1 can also reduce the generation of lipid peroxides and enhance the resistance to oxidative stress thus to reduce the level of intracellular reactive oxygen thereby inhibiting ferroptosis.
