Research progress on the role of butyrylation modification in malignant tumors
10.16352/j.issn.1001-6325.2025.11.1496
- VernacularTitle:丁酰化修饰在恶性肿瘤中作用的研究进展
- Author:
Dongxue SHI
1
;
Ruihan WANG
;
Beibei LYU
;
Xiaoyan LIN
Author Information
1. 山东第一医科大学附属省立医院病理科,山东济南 250021
- Keywords:
butyrylation;
malignant tumor;
post-translational modification
- From:
Basic & Clinical Medicine
2025;45(11):1496-1500
- CountryChina
- Language:Chinese
-
Abstract:
Butyrylation(Kbu),as an important post-translational modification(PTM)of proteins,precisely regu-lates various biological behaviors of tumor cells by modulating the structure and function of proteins.Abnormal bu-tyrylation promotes tumor cell proliferation and migration by regulating protein stability,enzyme activity,cell signa-ling pathways,chromatin structure and gene expression,and further participates in tumor occurrence and develop-ment.This review focuses on the role of butyrylation modification in the occurrence and development of various hu-man tumors,aiming to summarize the research progress of butyrylation modification in the field of tumors,and to provide new directions for tumor treatment through the intervention strategies of butyrylation modification.
