Role of anti-aging Klotho gene in inflammatory responses and fibrosis
10.16352/j.issn.1001-6325.2025.10.1382
- VernacularTitle:抗衰老Klotho基因在炎性反应和纤维化中的作用
- Author:
Min YE
1
;
Xiuying GUO
;
Danxin WANG
;
Guangliang HE
Author Information
1. 海南科技职业大学,海南 海口 571126;海南医科大学,海南 海口 570100;合江县中医医院,四川 泸州 646000
- Keywords:
Klotho;
anti-aging;
inflammation;
tissue fibrosis
- From:
Basic & Clinical Medicine
2025;45(10):1382-1386
- CountryChina
- Language:Chinese
-
Abstract:
The anti-aging Klotho gene can not only delay the aging process but also regulate fibrosis and inflamma-tory responses by influencing inflammatory cells such as monocytes-macrophages,T cells,and B cells.It can regu-late the processes related to fibrosis and inflammatory responses through inflammatory pathways such as fibroblast growth factor(FGF),transforming growth factor-β(TGF-β),Toll-like receptor(TLR),nuclear factor-κB(NF-κB),and the renin-angiotensin system(RAS).Thus,elucidating the molecular mechanisms by which Klotho regulates inflammatory responses and fibrosis,and developing targeted intervention strategies to upregulate Klotho levels based on these mechanisms,may provide new theoretical basis and therapeutic targets for the prevention and treatment of related diseases.
