Research progress on mitophagy in the development and treatment of osteosarcoma
10.16352/j.issn.1001-6325.2025.10.1377
- VernacularTitle:线粒体自噬在骨肉瘤发展和治疗中的研究进展
- Author:
Kangsheng NING
1
;
Chao YUN
;
Yi LI
;
Morigele
Author Information
1. 内蒙古医科大学附属医院 骨科,内蒙古 呼和浩特 010010
- Keywords:
osteosarcoma;
mitophagy;
cellular autophagy;
metabolic reprogramming;
signaling pathway
- From:
Basic & Clinical Medicine
2025;45(10):1377-1381
- CountryChina
- Language:Chinese
-
Abstract:
Mitophagy,as a highly conserved cellular defense mechanism,precisely recognizes and eliminates dys-functional or excessive mitochondria,thereby maintaining homeostasis of the mitochondrial network and providing a stable energy supply and raw materials for biosynthesis in cells.Mitophagy exerts regulatory effects on the develop-ment of osteosarcoma through multiple molecular mechanisms.Targeting this mechanism as a new strategy for thera-peutic intervention provides a solid theoretical foundation and set stage for exploring novel targeted therapies,there-by driving the field of osteosarcoma treatment towards more precise and efficient directions.
