Role of m6A methylation modification in bladder cancer
10.16352/j.issn.1001-6325.2025.10.1372
- VernacularTitle:m6A甲基化修饰在膀胱癌中的作用
- Author:
Yonghui LIU
1
;
Yan WU
;
Bo CHENG
Author Information
1. 山东第二医科大学 临床医学院,山东 潍坊 261053
- Keywords:
bladder cancer;
m6A methylation modification;
methyltransferase;
demethylase;
methylation reader
- From:
Basic & Clinical Medicine
2025;45(10):1372-1376
- CountryChina
- Language:Chinese
-
Abstract:
N6 methyladenosine(m6A)methylation modification is a common form of mRNA modification,which is involved in the regulation of mRNA output,splicing,translation,localization and degradation,and plays an important role in the regulation of gene expression,body growth and development,and the development of tumors.The expression levels of many m6A methylation-related molecules in bladder cancer are altered to varying degrees,thus affecting the clinical treatment and prognosis of bladder cancer.The m6A methylation modification is closely related to the occurrence and development of bladder cancer,and a deeper understanding of the relevant regulatory mechanisms is beneficial to provide more reference for the clinical application of m6A methyla-tion in bladder cancer.
