Distribution difference of T lymphocyte subsets in common and refractory mycoplasma pneumonia and its impact on clinical treatment
10.16352/j.issn.1001-6325.2025.10.1313
- VernacularTitle:T淋巴细胞亚群在普通型与难治性支原体肺炎中的分布差异及其对治疗的影响
- Author:
Lin ZHU
1
;
Shuqin FU
;
Wanyu JIA
;
Caili GUO
;
Chunlan SONG
Author Information
1. 郑州大学附属儿童医院 河南省儿童医院 郑州儿童医院 南区急诊综合病房,河南 郑州 450000
- Keywords:
mycoplasma pneumonia;
common mycoplasma pneumonia;
refractory mycoplasma pneumonia;
CD4+T lymphocytes;
CD8+T lymphocytes
- From:
Basic & Clinical Medicine
2025;45(10):1313-1317
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution difference of T lymphocyte subsets in common and refractory mycoplasma pneumonia and its impact on treatment.Methods Two hundred children with mycoplasma pneumonia hospitalized from October 2023 to January 2024 were retrospectively reviewed and divided into common mycoplasma pneumonia group and refractory mycoplasma pneumonia group(n=100 each)according to the severity of disease and treatment.The distribution of T cell immunophenotypes CD4+,CD8+and CD4+/CD8+were compared between common mycoplasma pneumonia and refractory mycoplasma pneumonia.The predictive value of CD4+,CD8+counting,CD4+/CD8+and combined detection on the occurrence of refractory mycoplasma pneumonia were ana-lyzed.Results Compared with the common mycoplasma pneumonia group,the refractory mycoplasma pneumonia group had more school-age children,longer fever duration and hospital stay(P＜0.05).Compared with the common mycoplasma pneumonia group,CD4+expression was slightly decreased in the refractory mycoplasma pneumonia group,but there was no statistical significance between the two groups;CD8+expression was significantly increased while CD4+/CD8+expression was significantly decreased(P＜0.05).Receiver operating characteristic curve(ROC)showed that CD4+(AUC=0.532,95%CI=0.455-0.608),CD8+(AUC=0.592,95%CI=0.515-0.666),CD4+/CD8+(AUC=0.579,95%CI=0.502-0.653)and combined detection(AUC=0.607,95%CI=0.531-0.680).Conclusions Compared with the common mycoplasma pneumonia group,CD4+expression is slightly decreased,CD8+expression is significantly increased,and CD4+/CD8+expression is significantly decreased in the refractory mycoplasma pneumonia group.All these indicators hold certain value in predicting the occurrence of refractory mycoplasma pneumonia,with combined detection demonstrating higher predictive value.
