Challenges and management strategies of anti-tumor treatment for renal insufficiency in elderly patients with malignant tumors
10.16352/j.issn.1001-6325.2025.10.1262
- VernacularTitle:老年恶性肿瘤患者肾功能不全的抗肿瘤治疗挑战与管理策略
- Author:
Chengyu ZENG
1
;
Wei QIU
;
Hua SONG
;
Xinying GUO
;
Hongyan YING
Author Information
1. 中国医学科学院 北京协和医学院,北京 100730
- Keywords:
renal insufficiency;
anti-tumor treatment;
elderly patients
- From:
Basic & Clinical Medicine
2025;45(10):1262-1269
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of malignant tumors among elderly patients is increasing.Influenced by multiple factors such as aging,tumor,and drug,this population exhibits a high prevalence of renal insufficiency.However,there remains a scarcity of research data and significant challenges in clinical management.This article systematically an-alyzes the challenges faced in administering anti-tumor therapies to elderly patients with renal insufficiency and pro-poses management strategies.Optimization approaches include precise assessment of renal function,selection of nephrotoxicity-sparing medications,appropriate dose adjustments,implementation of preventive measures,and em-phasis on comprehensive geriatric assessment and multidisciplinary collaboration.Renal injury management should be individualized,with considerations for special populations such as renal transplant recipients and dialysis pa-tients.Future efforts should focus on biomarker discovery and the development of low-nephrotoxicity therapeutic agents to address these complex clinical challenges.
