TMEM gene family in tumor development
10.16352/j.issn.1001-6325.2025.09.1243
- VernacularTitle:TMEM基因家族在肿瘤发生发展中的作用
- Author:
Caixia LING
1
;
Chunfang WANG
;
Yanhong LUO
Author Information
1. 右江民族医学院医学检验学院,广西 百色 533000;右江民族医学院生物医药与大健康现代产业学院,广西 百色 533000
- Keywords:
TMEM;
tumor;
angiogenesis;
post-translational modification of histone
- From:
Basic & Clinical Medicine
2025;45(9):1243-1247
- CountryChina
- Language:Chinese
-
Abstract:
The transmembrane protein gene family(TMEM)refers to a group of genes that encode trans-membrane proteins.The TMEM family influences tumor angiogenesis by affecting key signaling pathways involved in angiogen-esis,modulating the interactions between tumor cells and endothelial cells and regulating the expression or function of VEGF and its receptor VEGFR.Thereby it may have impact on tumor blood vessel formation.Additionally,the TMEM family regulates mechanisms such as post-translational modifications of histone,which also play a role in tumor initiation and progression.Post-translational modifications of TMEM proteins including phosphorylation,gly-cosylation,acetylation and palmitoylation.TMEM family contributes to tumorigenesis and may identify some novo targets used in precise medical treatment.
