Role of hydrogen sulfide in asthma
10.16352/j.issn.1001-6325.2025.09.1239
- VernacularTitle:硫化氢在哮喘中的作用
- Author:
Xinyue CUI
1
;
Shasha HAN
Author Information
1. 滨州医学院附属医院 呼吸内科学,山东 滨州 256603
- Keywords:
hydrogen sulfide;
asthma;
mechanism of action;
biomarker
- From:
Basic & Clinical Medicine
2025;45(9):1239-1242
- CountryChina
- Language:Chinese
-
Abstract:
Asthma is one of the most common diseases in chronic respiratory system;the etiology is complex,in-volving many types of inflammatory cells and a variety of signaling molecular mediators.Hydrogen sulfide(H2 S)is an endogenous gas transmitter in mammals,which is widely involved in cell functions and physiological and pathological processes of various diseases,including respiratory diseases.H2 S is involved in the occurrence and development of asthma through various ways.When the H2 S-producing enzyme level decreases,the concentration of endogenous H2 S level may trigger asthma attack and play a pro-inflammatory role.On the other hand,H2 S ini-tiates pulmonary inducible nitric oxide synthase(iNOS)activation,limiting airway remodeling,and acts as an anti-remodeling and anti-inflammatory mediator.Moreover,H2 S level varies at different stages of asthma.H2 S level in patients with asthma is a potential bio-markers of airway inflammation in asthma case and my support clin-ical diagnosis of asthma.
