Research progress on macrophage polarization during the degeneration process of lumbar intervertebral discs
10.16352/j.issn.1001-6325.2025.09.1229
- VernacularTitle:巨噬细胞极化影响腰椎间盘退变的研究进展
- Author:
Wang CHEN
1
;
Xugui LI
;
Ying LI
Author Information
1. 湖北中医药大学 针灸骨伤学院,湖北 武汉 430065
- Keywords:
lumbar intervertebral disc degeneration;
macrophage polarization;
immune microenvironment
- From:
Basic & Clinical Medicine
2025;45(9):1229-1233
- CountryChina
- Language:Chinese
-
Abstract:
During pathological progression of lumbar intervertebral disc degeneration(LIDD),macrophage po-larization functions as a critical regulatory mechanism through the dynamic transition between M1 and M2 pheno-types.The distribution of macrophages with distinct phenotypes is related to disease stages and the microenviron-ment,exerting dual effects by either exacerbating inter-vertebral disc degeneration or promoting its repair.Macro-phage polarization significantly influences LIDD primarily by modulating the inflammatory microenvironment of the lumbar intervertebral disc,inducing oxidative stress(OS),altering intervertebral disc cell activity,and regulating the degradation of the intervertebral disc extracellular matrix(ECM).
