Variations in GLP-1R rs2268641 increase risk of diabetic nephropathy in China
10.16352/j.issn.1001-6325.2025.09.1190
- VernacularTitle:GLP-1R rs2268641变异增加中国人糖尿病肾病风险
- Author:
Ke HE
1
;
Fan YANG
;
Xiwan LU
;
Yun HU
Author Information
1. 无锡市中医医院 (南京中医药大学附属无锡医院) 内分泌科,江苏 无锡 214000
- Keywords:
type 2 diabetes mellitus;
diabetic nephropathy;
glucagon-like peptide-1 receptor(GLP-1R);
genetic polymorphism
- From:
Basic & Clinical Medicine
2025;45(9):1190-1194
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between glucagon-like peptide-1 receptor(GLP-1R)gene polymorphism(rs2268641)and the incidence of diabetic nephropathy(DN)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 490 T2DM patients with or without DN were included in this project.GLP-1R genetic polymorphisms were genotyped with TaqMan allelic discrimination.Results The C allele of rs2268641 was significantly associated with DN in T2DM patients.As compare to urinary albumin excretion rate(UAER)among genotypes,CC homozygote had a higher level of UAER than CT heterozygous(P＜0.01)and TT homozygote(P＜0.05)respectively.CC homozygote had a higher level of UAER than the carriers of the T allele(P＜0.05).Univariate logistic regression analysis showed that CC homozygote had higher odds for DN than CT het-erozygote(OR:1.715,95%CI=1.058-2.778,P＜0.05),even after adjustment for age,gender,family history,FBG and HbA1c(OR:1.781,95%CI=1.076-2.947,P＜0.05).Moreover,the CC homozygote had higher odds for DN than the carriers of the T allele before(OR:1.585,95%CI=1.013-2.481,P＜0.05)and after adjustment(OR:1.660,95%CI=1.040-2.650,P＜0.05).Conclusions GLP-1R gene variants,especially the C allele of rs2268641 increase the risk of DN in Chinese T2DM patients.
